IMPORTANCE OF PHENYTOIN LEVEL MONITORING TO AVOID TOXICITY AND PERMANENT NEUROLOGICAL DAMAGE
نویسندگان
چکیده
منابع مشابه
Saliva carbamazepine and phenytoin level monitoring.
Saliva carbamazepine and phenytoin samples were used to monitor treatment in 35 children aged between 2 and 14 years during a 2-year period. All phenytoin levels and over half the carbamazepine levels that were above the therapeutic range were associated with adverse effects. Dose and carbamazepine saliva levels were significantly related but no such relationship was found for phenytoin. There ...
متن کاملPermanent neurological damage after spinal anaesthesia.
UNLABELLED The use of subarachnoid block for various surgeries is becoming common and it is without complications. There many complications of spinal anaesthesia but one of the devastating of such complications that can lead to permanent disability and psychological trauma for the anaesthetist is permanent neurological damage. METHOD This is a review article of various works on neurological d...
متن کاملQuality of Life Following Permanent Neurological Damage after Subarachnoid Block
Introduction. Caesarean section is the commonest operation carried out in females of the reproductive age group. Spinal anaesthesia is commonly used for caesarean section with its risk. Permanent paralysis of the lower limbs following subarachnoid block is a rare complication but can occur even in the best of hands. Case Summary. This is a 29-year-old final-year university student now 34 years ...
متن کاملPhenytoin Toxicity from Cocaine Adulteration
The use of phenytoin (PHT) as a cocaine adulterant was reported decades ago; that practice is still current. Ironically PHT has also been used for the treatment of cocaine dependence. A drug smuggler developed PHT toxicity after swallowing several rocks of crack. We investigated the current trends of PHT as a cocaine adulterant and its toxicological implications. We also reviewed the clinical u...
متن کاملIn-vitro lymphocyte toxicity to a phenytoin metabolite in phenytoin induced cutaneous adverse drug eruptions.
BACKGROUND Phenytoin, one of the most commonly used antiepileptic drug, is associated with a wide spectrum of adverse drug eruptions. It is metabolized by the hepatic microsomal enzymes. The intermediate metabolites are arene oxides which accumulate due to deficiency of the enzyme epoxide hydrolase. These are postulated to be associated with phenytoin induced hepatotoxicity and antiepileptic hy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chest
سال: 2020
ISSN: 0012-3692
DOI: 10.1016/j.chest.2020.08.803